AB-FUBINACA CANNABINOID For Sale

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AB-FUBINACA CANNABINOID can only be ordered if you are over 18 years of age.

Please ensure that AB-FUBINACA CANNABINOID is NOT controlled in the country/state to which you wish it to be delivered.

AB-FUBINACA CANNABINOID is not for human consumption.

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Description

AB-FUBINACA CANNABINOID For Sale

AB-FUBINACA CANNABINOID is not for human consumption.

Metabolite profiling of novel psychoactive substances (NPS) is critical for documenting drug consumption. N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (ADB-FUBINACA) is an emerging synthetic cannabinoid whose toxicological and metabolic data are currently unavailable. We aimed to determine optimal markers for identifying ADB-FUBINACA intake. Twenty-three metabolites were identified. Major metabolic pathways were alkyl and indazole hydroxylation, terminal amide hydrolysis, subsequent glucuronide conjugations, and dehydrogenation. We recommend ADB-FUBINACA hydroxyalkyl, hydroxydehydroalkyl and hydroxylindazole metabolites as ADB-FUBINACA intake markers. This is the first ADB-FUBINACA in vitro metabolism study.

Keywords: ADB-FUBINACA, synthetic cannabinoid, novel psychoactive substances, metabolism, hepatocytes, LC-HRMS
The authors would like to thank Tim Moeller of Bioreclamation IVT for his assistance with the incubations.
Identification of major metabolite markers is critical to guide synthesis efforts of manufacturers to provide suitable analytical standards and for further pharmacodynamic and pharmacokinetic studies

Here we report the synthesis and pharmacological characterization of AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, 5F-ADBICA, and several analogues. All synthesized SCs acted as high potency agonists of CB1 (EC50 = 0.24-21 nM) and CB2 (EC50 = 0.88-15 nM) receptors in a fluorometric assay of membrane potential, with 5F-ADB-PINACA showing the greatest potency at CB1 receptors. The cannabimimetic activities of AB-FUBINACA and AB-PINACA in vivo were evaluated in rats using biotelemetry.
The pharmacology of indole and indazole synthetic cannabinoid designer drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA and 5F-ADBICA | Request PDF.

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